Slowbro was already a solid pokémon in OU and in ORAS he gets a mega evolution.
Typing: Water/Psychic
Ability: Oblivion / Own Tempo / Regenerator --> Shell Armor
Stats: 95/75/110/100/80/30 --> 95/75/180/130/80/30
Notables Moves:
Calm Mind
Curse
Fire Blast
Focus Blast
Grass Knot
Ice Beam
Psychic
Psyshock
Rest
Scald
Slack Off
Sleep Talk
Thunder Wave
Toxic
Trick Room
So Slowbro was already a solid OU mon and Regenerator helped him doing his job as a physical wall very well. Mega Slowbro got a great buff in Defense and Special Attack and paired up with Calm Mind is can become a terrifying pokémon to face, which is even before mega evolving, very useful. Shell Armor may seem bad, but with the Calm Mind sets, you don't have to worry about those crits anymore.
Possible Sets:
CroBro
Slowbro @ Slowbroite
Ability: Oblivious / Regenerator
EVs: 252 HP / 252 Def / 4 SpA OR 252 HP / 16 Def / 240 SpD
Bold Nature
- Calm Mind
- Rest
- Sleep Talk
- Scald
This is the set you will probably face the most. 130 Special Attack combined with Calm Mind makes it really hard to break. However, this set can be beaten by either mons who don't give anything about Scald (Mega Sceptile, Toxicroak, Gastrodon, Vaporeon) so those pokémon need to be beaten before trying to sweep. But thanks to Regenerator Slowbro is still useful before mega-evolving
CMBro
Slowbro @ Slowbroite
Ability: Oblivious / Regenerator
EVs: 252 HP / 252 Def / 4 SpA OR 252 HP / 16 Def / 240 SpD
Bold Nature
- Calm Mind
- Slack Off
- Psyshock / Ice Beam
- Scald
This set is pretty much the same as the one before, but there are some differences. This set can, thanks to Psyshock, not easily be walled by things that 4x resist it (Kingdra, Mega Sceptile) or are immune to it (Vaporeon, Toxicroak) The main disadvantage over the CroBro set is that it is worn down by Toxic pretty easy, and due to the lack of rest you can't take that away. This can be solved by a user of Heal Bell or Aromatherapy, or predict another status like Burn and switch into that. The CroBro set is more reliable, but with more coverage, this one is probably better when played well
Offensive Bro
Slowbro @ Slowbroite
Ability: Regenerator
EVs: 252 HP / 252 Def / 4 SpA or 252 HP / 252 SpD / 4 SpA
Bold / Calm Nature
- Psyshock
- Scald
- Fire Blast / Ice Beam / Thunder Wave
- Slack Off
I have encountered this set a few time and it is in my opinion not as strong as the Calm Mind sets. However, the coverage is nice and a Fire Blast can come in very unexpected. The set works pretty much the same as the standard Slowbro set. It is a great wall and has a good supporting function with Thunder Wave and his nice coverage (not much resist Psychic + Water + Ice)
Conclusion:
Mega Slowbro can be really hard to wear down thanks to it's reliable recovery (Slack Off) and the fact he doesn't give a damn about status (Rest)
I managed to kill it a few times with a T-Wave + Taunt Thundurus where Taunt cripples Slowbro. However, after SR a +1 Scald can OHKO and when Taunt is predicted, Slowbro can just taunt and kill it the next turn as Thunderbolt won't kill without prior damage. So even a Taunt user with a supereffective STAB can't always kill Slowbro.
Tips Against Slowbro: Never let him set up to many Calm Minds. He can't be critted so after 2 Calm Mind boosts it's often gg (unless you have Breloom, M-Hera etc. but who uses CM if they are still in the game) Also, a combination of a water resist (not Azu, because burn hurts) + Toxic can really hurt it. As the water resist can beat the Resttalk Bro and Toxic can beat the SlackOff Bro.
Tips With Slowbro: Don't set up too early in the game. Always make sure possible counters are killed before setting up as they can end a (late game) sweep before more than 1 pokémon dies. Don't be afraid of letting him spread burns with scald before going mega. His pre-mega ability is awesome and make him a powerful pokémon before Mega / Calm Mind.


Typing: Water/Psychic
Ability: Oblivion / Own Tempo / Regenerator --> Shell Armor
Stats: 95/75/110/100/80/30 --> 95/75/180/130/80/30
Notables Moves:
Calm Mind
Curse
Fire Blast
Focus Blast
Grass Knot
Ice Beam
Psychic
Psyshock
Rest
Scald
Slack Off
Sleep Talk
Thunder Wave
Toxic
Trick Room
So Slowbro was already a solid OU mon and Regenerator helped him doing his job as a physical wall very well. Mega Slowbro got a great buff in Defense and Special Attack and paired up with Calm Mind is can become a terrifying pokémon to face, which is even before mega evolving, very useful. Shell Armor may seem bad, but with the Calm Mind sets, you don't have to worry about those crits anymore.
Possible Sets:
CroBro
Slowbro @ Slowbroite
Ability: Oblivious / Regenerator
EVs: 252 HP / 252 Def / 4 SpA OR 252 HP / 16 Def / 240 SpD
Bold Nature
- Calm Mind
- Rest
- Sleep Talk
- Scald
This is the set you will probably face the most. 130 Special Attack combined with Calm Mind makes it really hard to break. However, this set can be beaten by either mons who don't give anything about Scald (Mega Sceptile, Toxicroak, Gastrodon, Vaporeon) so those pokémon need to be beaten before trying to sweep. But thanks to Regenerator Slowbro is still useful before mega-evolving
CMBro
Slowbro @ Slowbroite
Ability: Oblivious / Regenerator
EVs: 252 HP / 252 Def / 4 SpA OR 252 HP / 16 Def / 240 SpD
Bold Nature
- Calm Mind
- Slack Off
- Psyshock / Ice Beam
- Scald
This set is pretty much the same as the one before, but there are some differences. This set can, thanks to Psyshock, not easily be walled by things that 4x resist it (Kingdra, Mega Sceptile) or are immune to it (Vaporeon, Toxicroak) The main disadvantage over the CroBro set is that it is worn down by Toxic pretty easy, and due to the lack of rest you can't take that away. This can be solved by a user of Heal Bell or Aromatherapy, or predict another status like Burn and switch into that. The CroBro set is more reliable, but with more coverage, this one is probably better when played well
Offensive Bro
Slowbro @ Slowbroite
Ability: Regenerator
EVs: 252 HP / 252 Def / 4 SpA or 252 HP / 252 SpD / 4 SpA
Bold / Calm Nature
- Psyshock
- Scald
- Fire Blast / Ice Beam / Thunder Wave
- Slack Off
I have encountered this set a few time and it is in my opinion not as strong as the Calm Mind sets. However, the coverage is nice and a Fire Blast can come in very unexpected. The set works pretty much the same as the standard Slowbro set. It is a great wall and has a good supporting function with Thunder Wave and his nice coverage (not much resist Psychic + Water + Ice)
Conclusion:
Mega Slowbro can be really hard to wear down thanks to it's reliable recovery (Slack Off) and the fact he doesn't give a damn about status (Rest)
I managed to kill it a few times with a T-Wave + Taunt Thundurus where Taunt cripples Slowbro. However, after SR a +1 Scald can OHKO and when Taunt is predicted, Slowbro can just taunt and kill it the next turn as Thunderbolt won't kill without prior damage. So even a Taunt user with a supereffective STAB can't always kill Slowbro.
Tips Against Slowbro: Never let him set up to many Calm Minds. He can't be critted so after 2 Calm Mind boosts it's often gg (unless you have Breloom, M-Hera etc. but who uses CM if they are still in the game) Also, a combination of a water resist (not Azu, because burn hurts) + Toxic can really hurt it. As the water resist can beat the Resttalk Bro and Toxic can beat the SlackOff Bro.
Tips With Slowbro: Don't set up too early in the game. Always make sure possible counters are killed before setting up as they can end a (late game) sweep before more than 1 pokémon dies. Don't be afraid of letting him spread burns with scald before going mega. His pre-mega ability is awesome and make him a powerful pokémon before Mega / Calm Mind.
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