There's been speculation in the past if this lead could work. It's good on real runs, but looks vulnerable on paper. It is also extremely hard to describe the set to its fullest potenial.. This set has high upside
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http://www.smogon.com/dp/pokemon/smeargle
[SET]
name: Spiker Lead
move 1: Spore
move 2: Spikes
move 3: Endeavor
move 4: ExtremeSpeed/Magic Coat/Protect/Counter
item: Focus Sash
nature: Jolly / Hasty
ability: Own Tempo
evs: 4 HP/ 252 Atk / 252 Spe
[SET COMMENTS]
<p>Smeargle can make a fantastic support lead. Because of its access to Spore and Spikes, it can cripple a good amount of common leads and set up. The strategy is simple. Spore the opposition and then proceed to use Spikes. Spore allows you to cripple slower leads like Swampert and Bronzong and guarantees at least one layer of Spikes. Focus Sash also allows some safety versus faster leads, so it can status a Pokemon with Spore or lay down more Spikes. It is recommended to pair this set with a phazer to allow Spikes damage to accumlate and hinder some threats.</p>
<p>Smeargle's abysmal overall defenses make Endeavor an excellent option. With low HP or the activation of your Focus Sash, Smeargle is able to pummel any opposing foes to the ground(except Ghost-Types.) Stall teams are absolutely wrecked by the combo of Spore+Endeavor because of their overall low Speed not being able to outpace Smeargle(excluding Ghost-Types.) If used to its maximum potential, this strategy can ruin a good amount of pokemon. The last option is up to you. ExtremeSpeed allows Smeargle to finish off any Pokemon who has been hit by Endeavor or revenge kill any weakened pokemon. Magic Coat can be used to bounce back faster sleep moves from the likes of Roserade. Protect can be used in the last slot to stop Fake Out from ruining Focus Sash and scout potential moves. Lum Berry Metagross has the potency to ruin this set, so Counter can be an option to destroy any Metagross that opts to attack it. It can also scare Metagross to switch to another pokemon, allowing you to Spore or Spike the following turn. Jolly nature and max Speed allow full potential support. Attack EVs are added for maximum, revenge-killing power. Hasty nature should be used in tandem with Counter to increase its damage output.</p>
<p>Any faster Taunt users can stop Smeargle from setting up. Without Protect, Fake Out users enjoy forcing Smeargle to switch out. Although not very common, Lum Berry leads like Metagross can especially stop it up with any attack move. You should also be wary of Jirachi leads because of Iron Head flinches. </p>
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http://www.smogon.com/dp/pokemon/smeargle

[SET]
name: Spiker Lead
move 1: Spore
move 2: Spikes
move 3: Endeavor
move 4: ExtremeSpeed/Magic Coat/Protect/Counter
item: Focus Sash
nature: Jolly / Hasty
ability: Own Tempo
evs: 4 HP/ 252 Atk / 252 Spe
[SET COMMENTS]
<p>Smeargle can make a fantastic support lead. Because of its access to Spore and Spikes, it can cripple a good amount of common leads and set up. The strategy is simple. Spore the opposition and then proceed to use Spikes. Spore allows you to cripple slower leads like Swampert and Bronzong and guarantees at least one layer of Spikes. Focus Sash also allows some safety versus faster leads, so it can status a Pokemon with Spore or lay down more Spikes. It is recommended to pair this set with a phazer to allow Spikes damage to accumlate and hinder some threats.</p>
<p>Smeargle's abysmal overall defenses make Endeavor an excellent option. With low HP or the activation of your Focus Sash, Smeargle is able to pummel any opposing foes to the ground(except Ghost-Types.) Stall teams are absolutely wrecked by the combo of Spore+Endeavor because of their overall low Speed not being able to outpace Smeargle(excluding Ghost-Types.) If used to its maximum potential, this strategy can ruin a good amount of pokemon. The last option is up to you. ExtremeSpeed allows Smeargle to finish off any Pokemon who has been hit by Endeavor or revenge kill any weakened pokemon. Magic Coat can be used to bounce back faster sleep moves from the likes of Roserade. Protect can be used in the last slot to stop Fake Out from ruining Focus Sash and scout potential moves. Lum Berry Metagross has the potency to ruin this set, so Counter can be an option to destroy any Metagross that opts to attack it. It can also scare Metagross to switch to another pokemon, allowing you to Spore or Spike the following turn. Jolly nature and max Speed allow full potential support. Attack EVs are added for maximum, revenge-killing power. Hasty nature should be used in tandem with Counter to increase its damage output.</p>
<p>Any faster Taunt users can stop Smeargle from setting up. Without Protect, Fake Out users enjoy forcing Smeargle to switch out. Although not very common, Lum Berry leads like Metagross can especially stop it up with any attack move. You should also be wary of Jirachi leads because of Iron Head flinches. </p>