Icicle Crash deals with Grass-, Flying-, and Dragon-types, allowing Mamoswine to significantly damage walls such as Amoonguss, Celesteela, and Kommo-o. Icicle Spear can be considered instead to break the Substitutes of Kyurem and Galarian Moltres, but it is less consistent than Icicle Crash. Earthquake deals with Steel- and Water-types that resist Icicle Crash such as Aegislash and Toxapex. Superpower heavily dents Pokemon that are not bothered by the first two moves, such as Porygon2, Cloyster, Air Balloon Heatran, and Ferrothorn. Knock Off may be considered over Superpower to cripple physical walls such as Slowbro, Galarian Corsola, and Rotom-W. Ice Shard allows Mamoswine to revenge kill weakened threats such as Hydreigon, Galarian Moltres, and Choice Scarf Tapu Bulu. It also lets it clean up Flying and Dragon teams late-game when their walls have been sufficiently chipped. A Choice Band allows Mamoswine to OHKO walls such as Amoonguss, Zapdos, and Toxapex with the appropriate STAB move. An Adamant nature lets Ice Shard better pick off threats such as Thundurus-T, Galarian Moltres, and Tapu Bulu. Thick Fat allows Mamoswine to check SubRoost Kyurem and remove Ice-types such as Galarian Darmanitan in a pinch.

Excadrill is a good teammate to eliminate fast threats Mamoswine struggles with such as Zeraora, Volcarona, and Blacephalon when used on sand teams, or it can provide Rapid Spin support and clean late-game on weather-less teams once Mamoswine has chipped opposing walls. Gastrodon provides a Water immunity, can spread Toxic to wear down the opposing team, and can take special attacks aimed at Mamoswine. Alternatively, Seismitoad may be considered as the Water-immune partner, as it can check Azumarill, which usually poses a huge threat for Ground teams. Landorus-T provides Gravity support to allow Mamoswine to break through checks such as Rotom-W and Celesteela that can normally wall it. Swords Dance Garchomp can work alongside Mamoswine to break through their shared checks such as Slowbro and Kyurem when facing Psychic and Dragon teams. Nidoking deals with physical walls such as Slowbro and Ferrothorn that Mamoswine struggles with. Hippowdon can take physical attacks from Zeraora and Victini aimed at Mamoswine and can set sand and Stealth Rock to chip the opposing team further.

Mamoswine is an effective wallbreaker on Ice teams, as it helps pressure Fire-, Rock-, and Steel-types such as Torkoal, Tyranitar, and Heatran. Earthquake makes it a dangerous threat for Poison and Electric teams, and Icicle Crash hits Ground-immune targets like Celesteela, Zapdos, and Mantine. Ice Shard provides priority and aids in revenge killing the likes of Agility Galarian Moltres, Choice Scarf Galarian Zapdos, and Choice Scarf Thundurus-T. Superpower grants Mamoswine the ability to break past bulky Pokemon such as Ferrothorn and Porygon2. Heavy Slam can be used to reliably defeat setup sweepers such as Hatterene and Clefable. Knock Off is a great utility option that allows Mamoswine to get rid of important items such as Eviolite from Chansey, Porygon2, and Piloswine as well as recovery items from Ferrothorn and Slowbro. An Adamant nature lets Mamoswine better revenge kill the aforementioned targets of Ice Shard.

Kyurem appreciates Mamoswine breaking through Steel-types such as Aegislash and Melmetal, as they are able to tank Kyurem's Earth Powers quite easily. In return, Kyurem checks Rotom-W and Slowbro and is capable of PP stalling Ferrothorn's Gyro Ball and Corviknight's Body Press with Pressure. Arctozolt not only helps Mamoswine break down defensive cores used by Poison and Flying teams, but also threatens Water-types such as Pelipper, Volcanion, and Toxapex. Cloyster values Mamoswines immunity to Electric-type moves from Tapu Koko, Zapdos, and Alolan Raichu, while also setting Spikes to support Mamoswine's wallbreaking by providing chip damage against foes. Aurora Veil Alolan Ninetales allows Mamoswine to tank more hits and wallbreak for a prolonged period of time; Alolan Ninetales also checks threats such as Urshifu-R and Kommo-o. Galarian Darmanitan can use Flare Blitz to KO Ferrothorn for non-Superpower Mamoswine and also lures Ground-immune Steel-types like Corviknight and Celesteela. Mamoswine wears down bulky teams so that Weavile can sweep in the late-game, while Weavile's Speed is great for dealing with faster threats such as Volcarona, Spectrier, and Blacephalon.