Mega Tyranitar is a valuable asset for a variety of teams due to the sheer role compression it provides. It can act as an entry hazard setter; an offensive threat with its STAB moves, coverage, and high Attack stat; and a trapper with its effective usage of Pursuit, allowing it to remove offensive threats such as Choice-locked Tapu Lele and Gholdengo. Due to its incredible capabilities as an offensive threat, it can check many common special attackers such as Raging Bolt, Mega Charizard Y lacking Focus Blast, and Terapagos while dealing significant damage and threatening them with Pursuit. Even though Stone Edge is very powerful with STAB, other options can also be run, such as Ice Punch for doing significant damage to Landorus-T and Great Tusk while scoring an OHKO on Gliscor and Garchomp as well as Low Kick for hitting Steel-types such as Ferrothorn, Kingambit, and Melmetal that would otherwise threaten Mega Tyranitar. Stealth Rock is a priority on Mega Tyranitar due to its great bulk and ability to check common entry hazard removal options such as Terapagos, Zapdos, and Tornadus-T lacking Focus Blast. Even though Mega Tyranitar is an exceptional Stealth Rock setter, Low Kick can be run if there is already another Stealth Rock setter on the team. Knock Off has excellent synergy with Stealth Rock, as it can remove items like Heavy-Duty Boots from common users such as Alomomola and Toxapex, making them vulnerable to hazards. 164 Speed EVs allow Mega Tyranitar to outspeed non-Speed invested Landorus-T and maximum Speed invested Jolly Kingambit.

Mega Tyranitar fits best on many balance and bulky offense teams that can benefit heavily from its role compression. It can also fit on entry hazard stacking teams, as it can set hazards and use Knock Off to remove foes' Heavy-Duty Boots while also setting sand to deal additional chip damage. Even though Mega Tyranitar has great offensive and defensive stats, its lackluster typing holds it back significantly. It struggles against powerful Fighting-types such as Zamazenta, Mega Lopunny, and Great Tusk along with viable Fairy-types such as Iron Valiant, Tapu Lele, and Mega Mawile. Teammates such as Gholdengo, Clefable, and Zapdos can check most of the Pokemon mentioned above, while Iron Valiant and Melmetal can offensively threaten Tapu Lele and opposing Iron Valiant. Additionally, Future Sight users such as Tapu Lele and Galarian Slowking can form powerful cores with Mega Tyranitar, as they help it in breaking the aforementioned Zamazenta, Great Tusk, and Iron Valiant. In return, Mega Tyranitar can weaken Pokemon that can safely switch into Future Sight such as Kingambit if running Low Kick and Gholdengo with Knock Off. As a teammate, Gholdengo can block Rapid Spin from Great Tusk and blocks Defog from physically defensive Corviknight.