With the highest base Speed in the game, Regieleki can enable high-powered setup sweepers like Manaphy, Kingambit, and Iron Hands on hyper offense teams as a dual screens lead, though it's more niche than other dual screens setters. With Refrigerate, Rapid Spin is a guaranteed way to remove entry hazards even in the face of Ghost-types like Gholdengo and Pecharunt. However, Regieleki isn't the best to rely on for Rapid Spin all of the time, so teammates like Great Tusk and Quaquaval can help as additional spinners. Explosion lets Regieleki get its teammates in safely, do massive damage to foes like Swampert, Great Tusk, and Roaring Moon, and prevent dual screens removal via Defog. Many setup sweepers, most notably Gholdengo and Iron Hands, appreciate Regieleki's dual screens support while also fending off priority from Pokemon like Slither Wing and Prankster Corviknight, which would otherwise prevent it from setting dual screens. Regieleki similarly doesn't enjoy Choice Scarf Roaring Moon and Meowscarada, as they are the only relevant Pokemon able to outspeed it instantly, so having checks to them such as Kingambit, Iron Hands, and Zamazenta can help. As a final note, Regieleki is exclusively a hyper offense lead meant to support Pokemon such as Iron Boulder, Gengar, and Kingambit by providing them with extra opportunities to set up and win the game.