Amoonguss's great typing, access to Regenerator, and excellent toolkit allow it to function as a top-notch support Pokemon with the ability to check and, with Spore, shut down Raging Bolt, Urshifu-R, and Zamazenta-C throughout the game. Amoonguss uses Pollen Puff to heal its teammates, providing its team the upper hand in longer games. However, Sludge Bomb can be used instead of Pollen Puff or Protect to 2HKO the Ogerpon formes that can redirect Spore. Amoonguss uses Rocky Helmet to better answer Urshifu-R and break Focus Sash on Mienshao, Chien-Pao, and Urshifu-S. Amoonguss can opt for Covert Cloak to obtain a Fake Out immunity. Mental Herb can be used instead to protect against Taunt from Tornadus and Incineroar. Sitrus Berry can also be used for burst healing, allowing Amoonguss to avoid the 2HKO from Tornadus's Bleakwind Storm. The EV spread with a Bold nature allows Amoonguss to survive Adamant Chien-Pao's Icicle Crash and, with Sitrus Berry, avoid the 2HKO from Flutter Mane's Shadow Ball. A Calm nature lets Amoonguss avoid the 2HKO from Calyrex-S's Astral Barrage and survive Chien-Pao's Ice Spinner. 27 Speed IVs make Amoonguss slower than Calyrex-I, so it can use Spore before Calyrex-I moves under Trick Room. Amoonguss prefers Tera Fairy to check Miraidon and have a neutral matchup against the majority of the metagame. Tera Water is to answer Koraidon and Calyrex-I while keeping the resistance to Water. This is good because it allows Amoonguss to take on common duos like Chien-Pao + Urshifu-R. Tera Dark can be used to resist Calyrex-S's Astral Barrage and gain an immunity to Tornadus's Prankster Taunt.

Amoonguss struggles against Pokemon that ignore Spore and Rage Powder such as Rillaboom, Ogerpon-H, Safety Goggles Incineroar, and Tera Grass Calyrex-I. This makes Incineroar a great partner, as it can threaten the Grass-types and use Knock Off to remove opposing Safety Goggles. Pelipper helps Amoonguss with rain and Wide Guard, protecting it from Calyrex-I's Glacial Lance. Pelipper can also use Hurricane and Weather Ball to pressure the aforementioned Amoonguss checks. Amoonguss can help Incineroar and Pelipper by redirecting Urshifu-R's and Raging Bolt's threatening STAB moves, respectively.