Extreme Killer Arceus is a niche pick in Anything Goes due to its powerful STAB priority and plethora of useful coverage moves giving it a positive matchup against both offensive and bulkier builds. Extreme Speed allows Arceus to OHKO a significant portion of the offensive metagame after Swords Dance. It also provides teams with a way to revenge kill runaway sweepers such as Yveltal, Xerneas, and Mega Rayquaza. Earthquake allows Arceus to hit common Pokemon that take Extreme Speed well, such as the omnipresent Necrozma-DM, Zacian-C, and Primal Groudon. Ice Beam is the preferred fourth move due to its ability to OHKO untransformed defensive Zygarde-C without Dynamaxing. A Naughty nature is preferred in order to take priority attacks from the likes of Mega Rayquaza and opposing Arceus slightly better without compromising Arceus's offensive presence. A Naive nature may be run in order to outspeed Jolly Mega Rayquaza and at worst Speed tie with opposing Arceus.

Due to Arceus's typing and lower Speed, it is easily defeated by the omnipresent Zacian-C, so it fits best on hyper offense teams capable of providing Sticky Web support. As such, good teammates for Arceus are Sticky Web setters such as Smeargle and Shuckle. Additionally, Arceus aids in Imposter-proofing Arceus-Ghost, since it's immune to Shadow Force, as well as most other hyper offensive staples such as Yveltal, Xerneas, Ultra Necrozma, and Mega Rayquaza, as it can pick off a weakened Ditto transformed into these threats with Extreme Speed. With Dynamax, it massively damages or outright OHKOes the metagame's premier Defogger in Ho-Oh, further making it a good asset to offense. Depending on the matchup, Arceus can serve as a wallbreaker, late-game cleaner, or both, making fellow wallbreakers and late-game cleaners good teammates in general. Arceus is particularly notable for its ability to get rid of Zygarde-C, making wallbreakers such as offensive Primal Groudon, Dragon Dance Mega Rayquaza, Ultra Necrozma, and Necrozma-DM great team options. All of these can also put severe pressure on Lunala and Ferrothorn, which might otherwise greatly trouble Arceus. Lastly, good fellow late-game cleaners include the aforementioned Mega Rayquaza and Ultra Necrozma, as well as Xerneas and Yveltal.